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KMID : 1189420070200010169
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 1 p.169 ~ p.176
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Study of Gagamtongsung-San about cytotoxicity in L1210
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Park Youn-Hee
Choi Jung-Hwa
Kim Jong-Han
Park Su-Yeon
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Abstract
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Objectives: The purpose of this study was to investigate inhibitory effect of Gagamtongsung-San(GTS) on the cancer.
Methods: This study estimated the cytotoxicity of GTS about L1210 and NIH3T3. We used GTS extract distilled with water, n-Hexane, Ethyl acetate and Butanol. The cytotoxicitys of GTS about cancer cells and normal cells were tested using a colorimetric tetrazoliun assay(MTT assay).
Results: The results of this study were obtained as follow ; l. Cytotoxicity of water extract of GTS in L1210 cell lines was significantly increased, compared with NIH3T3. 2. n-Hexane fraction of GTS had similar cytotoxicity between L1210 and NIH3T3, and that have similar IC?? of water extract of GTS at 276 ug/ml 3. Ethyl acetate fraction of GTS had low degree cytotoxicity both L1210 and NIH3T3 cell lines. 4. Butanol fraction of GTS had cytotoxicity between L1210 and NIH3T3. Significantly, Cytotoxicity of GTS in L1210 cell lines was significant increased. 5. H₂O fraction of GTS had no cytotoxicity both L1210 and NIH3T3.
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KEYWORD
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Gagamtongsung-San, anticancer
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